Long-term Antidepressant Effect of Repeated Ketamine Administration


Long-term Antidepressant Effect of
Repeated Ketamine Administration

Although ketamine has a fast-acting antidepressant effect, it typically only lasts for about a week before depressive symptoms re-emerge. Furthermore, it is typically administered via intravenous infusion, which requires the person be in a medical setting.
In this study, it was found ketamine had a rapid-acting antidpressant effect when administered intranasally. Furthermore, these effects were maintained for 8 weeks with repeated administrations, beginnning at twice per week, and decreasing to once per week. This is the first trial showing the potential to use ketamine as a long-term antidepressant.

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